Doctors define erectile dysfunction as a persistent (continuing for longer than 3 months) inability to achieve and maintain a sufficiently strong erection for a full sexual intercourse. Recent clinical studies have shown a wide prevalence of such a disease.

Almost half of men from 30 to 45 years suffer from an insufficiently potent potency throughout the world, and with age statistics are even more sad. Cialis instruction on the use of which indicates erectile dysfunction as the main indication for taking medication, is one of the three most frequently prescribed medications for restoring potency.

Erection occurs when a combination of reflexes of the nervous and cardiovascular system, which are under the control of the hormonal endocrine system. The physiological mechanism of potency is to expand the arteries and relax the smooth muscles of the cavernous bodies of the genital organ.

Under the influence of sexual excitement, the release of biologically active compounds occurs, the blood vessels of the penis expand, and the blood flows to the penis.

Until  the 1990s , medicines and dietary supplements were often used to treat erectile dysfunction, for example, the widely known Yohimbine. However, during clinical trials, the effect of the use of such medications was only 30% better than taking a placebo (“dummies”).

Sildenafil – the main component of the generic Viagra , manufactured by Pfizer, was approved for clinical use in 1997 in the United States. He became the first drug from the group of phosphodiesterase inhibitors of the fifth type. Currently, along with Viagra and its numerous analogues under different brands, other, more modern medicines of this group are used: tadalafil (Cialis, producer – pharmaceutical corporation Eli Lilly, USA) and vardenafil (Levitra from GlaxoSmithKline).

The main component of the preparation Cialis instructions for use calls tadalafil. The mechanism of cialisits operation is based on the following effect. In the event of sexual arousal, nitric oxide (the chemical formula NO) penetrates through the membranes of myocytes of smooth muscle and activates the enzyme guanylate cyclase. This leads to an enhanced synthesis of cyclic guanosine monophosphate (cGMP). As a result of such processes, the capacity of potassium and calcium channels of myocytes varies. This is accompanied by a relaxation of the smooth musculature of the vessels of the cavernous bodies of the penis.

Accordingly, the reverse process leads to an increase in the tone of the circulatory network, the outflow of blood and the weakening of the erection. The cleavage of cyclic guanosine monophosphate occurs under the influence of phosphodiesterase of the fifth type (abbreviated as FDE-5). It is on the inhibition of the activity of this enzyme that the action of tadalafil, the main component of Cialis, is based.

The drug is available in the form of tablets with a dosage of active ingredient 20 or 5 mg.

IT IS IMPORTANT

On some sites advertising the questionable quality of funds for improving potency, Cialis Soft is offered, which also contains tadalafil, but does not have the appropriate license.

According to the doctors, Cialis, the instructions for use of which details all the advantages of the medication, is much more effective than the common Viagra, although the price of these medicines is almost the same. However, sildenafil is prescribed almost as often as tadalafil. Most experts attribute this to the successful advertising campaign of Pfizer Corporation.

In contrast to the previously used inhibitors of phosphodiesterase type 5, the effect of Cialis lasts up to one and a half days, which makes you feel more relaxed in bed. However, the stimulus to increase the secretion of hormones, the release of nitric oxide and a further cascade of physiological processes is sexual arousal.

IT IS IMPORTANT

Treatment of violations of potency with the help of Cialis will be effective only if there is a sexual attraction. Therefore, if the basis of erectile dysfunction is hormonal or psychological decline of libido, tadalafil, like other drugs with a similar effect, will be ineffective.

After ingestion, the drug is quickly absorbed from the digestive tract. The therapeutic concentration of the active component in the blood is reached after 0.5 – 2 hours. On the dependence on the intake of the pharmacokinetics of the preparation Cialis instruction does not indicate, but clinical studies indicate that too fatty foods and alcohol can slow the absorption of tadalafil from the gastrointestinal tract.

The half-life of the drug is an average of 17.5 hours. The drug appears in the form of inactive compounds through the digestive system (up to 65%) and with urine (35%). With blood plasma proteins, the drug binds more than 90%, the sperm practically does not penetrate. In the absence of restrictions on the use of Cialis in seminal fluid, less than a tenth of a percent of active tadalafil is detected.

IT IS IMPORTANT

The drug selectively affects phosphodiesterase type 5 and practically does not affect other forms of the enzyme located in the brain, blood vessels, muscle tissue, respiratory tract, retina. Therefore, the side effects of taking Cialis are expressed to a much lesser extent than other drugs of the class of PDE-5 inhibitors.

The drug is prescribed for the treatment of erectile dysfunction, which is not accompanied by a decrease or total absence of sexual desire. In the medical literature there is evidence of the appointment of Cialis medication, the instruction for the use of this fact does not reflect, in order to alleviate the symptoms of chronic prostatitis and prostate adenoma. In the course of therapy, sexual activity is restored, but blood flow in the pelvic organs is stimulated, which reduces the manifestations of inflammatory processes in the prostate.

effect of cialis

Cialis: side effects, contraindications, overdose symptoms

Inhibitors of phosphodiesterase of the fifth type are referred to as potent drugs.

Therefore, to their application, there are certain limitations associated with the influence on the work of the cardiovascular system and the features of the distribution of tadalafil in the body.

First of all, doctors emphasize that clinical studies on the effect of the drug on children and adolescents under the age of 18 have not been conducted.

Also, due to the limited evidence for use, there was no question of the safety of the use of the drug in bearing and breastfeeding.

In addition, contraindications for the appointment of Cialis for the treatment of erectile dysfunction are:

  • high risk of allergic reaction to tadalafil and other auxiliary components of tablets;
  • lactose intolerance;
  • lactase insufficiency;
  • a recent heart attack or stroke (in the previous 90 days for myocardial damage and half a year for violations of the central circulation);
  • angina pectoris;
  • spontaneous attacks of arterial hypotension or hypertension;
  • severe course of chronic heart failure;
  • loss of vision associated with ischemic impairment.

Regarding the use of Cialis medication, side effects have been investigated in almost 5,000 healthy men worldwide. Only 3% of patients had to stop taking the medication because of undesirable consequences.

When combined with tadalafil other medications, the following points should be considered:

  • Cialis is contraindicated to take simultaneously with organic nitrates and α-adrenoblockers because of the high risk of complications from the cardiovascular system;
  • the drug is incompatible with other drugs for the treatment of erectile dysfunction;
  • ketoconazole, itraconazole, medications for HIV therapy and some antibiotics (eg, erythromycin) increase the activity of Cialis;
  • rifampicin, phenobarbital and carbamazepine depress the activity of tadalafil;
  • simultaneous administration with antacids does not affect the concentration of Cialis, but reduces the rate of its absorption;
  • tadalafil slightly increases the effect of antihypertensive drugs.

The instructions for use indicate that even a long reception of Cialis is not addictive. In the absence of other concomitant diseases, the drug is taken at the recommended dosage.